Aging ― Lost in Translation?
Author: Kapahi P, Vijg J
Journal: N Engl J Med 361:2669, December 31, 2009 Clinical Implications of Basic Research
Extending the span of a healthy life has fascinated humanity ever since Gilgamesh failed to prevent his dying friend Enkidu from descending into the horrific netherworld, as described in the epic poem from ancient Iraq. Recent discoveries in the research on aging suggest that modern science is more adept at keeping aging at bay ― at least temporarily and thus far only in worms, flies, and rodents1 ― than at halting it completely. A recent study by Selman and colleagues2 has identified ribosomal protein S6 kinase 1 (S6K1) as a molecular player in the aging game.
NEJMのClinical Implications of Basic ResearchあるいはMechanisms of Diseaseはわかりやすく最先端のサイエンスと臨床のつながりをコンサイスでまとめてくれるのでありがたい。
驚くべきことにこのmTORを抑えると実験動物で長寿を得ることがわかってきた。1) さらにmTORはAMPAという細胞内のエネルギー量のセンサーとなる蛋白の働きを抑えてしまうが、糖尿病薬のメトフォルミンは、AMPA活性を上げることで、同じように寿命を延ばすことも報告されている。2)

1.Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late
in life extends lifespan in genetically heterogeneous mice. Nature
2. Anisimov VN, Berstein LM, Egormin PA, et al. Metformin
slows down aging and extends life span of female SHR mice.
Cell Cycle 2008;7:2769-73.
サイトマップ サイトポリシー プライバシーポリシー お問い合わせ