The type 5 phosphodiesterase inhibitor tadalafil influences salivary cortisol, testosterone, and dehydroepiandrosterone sulphate responses to maximal exercise in healthy men.
Author: Di Luigi L, Baldari C, Sgrò P, Emerenziani GP, Gallotta MC,
Bianchini S, Romanelli F, Pigozzi F, Lenzi A, Guidetti L.
Journal: J Clin Endocrinol Metab. 2008 Sep;93(9):3510-4. Epub 2008 Jun 17.
Context: Physical exercise-related stress activate hypothalamus-pituitary-adrenal (HPA) axis, nitric oxide (NO) is one of the mediators of the HPA axis response to stress, and phosphodiesterase type 5 inhibitors (PDE5i) influences NO-linked biological activities.
Objective: To investigate whether a single oral long half-life PDE5i (tadalafil) administration influences the HPA axis response to exercise-related stress.
Design: Double blind crossover trial
Participants: Nine healthy male athletes
Interventions: All subjects performed a maximal exercise test in normoxia, after received a single oral administration of tadalafil or placebo. Then, after a 2-weeks washout period, they were crossed over and repeated the exercise test. Each subject was is own control. Salivary collections, for steroids evaluations [cortisol, dehydroepiandrosterone sulphate (DHEAS), testosterone] and respective ratios calculation (DHEAS/cortisol, testosterone/cortisol, testosterone/DHEAS), were performed before each exercise (Pre-Ex), immediately after (Post-Ex), and at thirty minutes during recovery.
Results As expected mean salivary cortisol concentration increased immediately after exercise both after tadalafil and placebo (p = 0.014, and p =0.036 vs Pre-Ex, respectively), however, the cortisol increase was significantly higher after tadalafil administration (p = 0.034 vs placebo). Furthermore, an increased salivary testosterone after exercise was observed only after tadalafil administration (p = 0.029 vs Pre-Ex). No effects of either exercise and/or tadalafil administration on salivary DHEAS concentrations were observed. DHEAS/cortisol and testosterone/cortisol ratios significantly decreased after exercise after tadalafil administration (p = 0.037, and p = 0.02 vs placebo, respectively).
Conclusion Tadalafil administration amplified the salivary cortisol and testosterone responses to a maximal exercise-related stress in healthy trained humans.
われわれもシルデナフィルの定期的な投与がテストステロンを上げ、酸化ストレスを減少させることを報告(J Sex Med 2008;5:1482?1491.)しているが、PDE5阻害薬には、ED治療以上の重要な作用がある可能性が期待される。それがcGMPと関係あるのか興味がある。
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