Knapsack

The Language of Life

執筆 : 
Shigeo Horie 2010-7-17 23:00
The Language of Life: DNA and the Revolution in Personalized Medicine Francis S. Collins

ヒトgenomeが解読されても、画期的な創薬がなされたのだろうか?
genomeはまず入り口で、proteome, transcriptome, などさまざまな分子複合体の解析が進んでいる。
とはいえ、究極の個人情報であるゲノムがどう医学の進歩に関係するのか、底抜けに明るい夢を表わしているのが本書である。
著者のFrancis S. Collinsはゲノムプロジェクトの中心で現在NIHの長官。
実はオバマ大統領もゲノム医学になみなみならぬ可能性を見抜いていた。
もちろん、ビジネスとしての側面もあるが。

本書の内容はきわめて簡単で、DNA医学の進歩が疾患リスクを呈示し、また最適の治療薬を最適の治療量で服薬することで、効果を最大にできる、というものである。
たとえば、Googleが出資していることで有名な23andme など、DNA検査のサイトも掲載されており、現在のDNA医学が偏りなく、比較的平易な英語で解説されているので、医学生にも良い教科書と思われる。
実際に、乳がんでは、乳がんが作っているたんぱく質の種類により既に抗がん剤の選択が定まっている。
いわば細菌に対して感受性のある抗生物質を選ぶようなもので、この20年のDNA医学は実際に医療に応用されている。
今年から、世界で最も権威がある医学雑誌のNew England Journal of Medicineでもこのgenome medicineの連載が不定期に始まっている。

さて、特にアメリカではこのDNAとキリスト教的な神との整合性が問題になる。
進化論がにわかには受け入れられない部分もある国。
Collinsは、The Language of Godという本でこの問題にある程度の見通しをつけようとしている。
DNAを哲学でどう考えるのか、われわれには考えつかないが。
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